Document Type
Thesis
Publication Date
2013
Abstract
Individuals with abdominal obesity are at higher risk for developing type 2 diabetes, predisposing cardiovascular events and insulin resistance. Low glycemic index (GI) diets may be beneficial in the management of insulin resistance. Insulin resistance is associated with increased intramyocellular lipid (IMCL) content as measured by proton nuclear magnetic resonance spectroscopy (1H-MRS). The primary objective of this thesis was to determine whether a low GI diet can improve insulin sensitivity by reducing IMCL of skeletal muscle. One hundred and twenty-one male and female participants aged 30 to 70 years (mean+SD, 53+10)) with abdominal obesity, entered a 4 to 6 week weight-maintaining, low-fat dietary advice run-in phase. Of the 121 eligible participants, 95 completed the run-in phase and were randomly assigned to either a low-GI (LGID, n=48) or high-GI diet (HGID, n=47) for 24 weeks. Participants underwent a 75g oral glucose tolerance test (OGTT) and had soleus-muscle IMCL measured by 1H-MRS at the beginning and end of the intervention period. Insulin sensitivity was assessed by the homeostatic model assessment index (HOMA) and the insulinogenic index (ISI) was calculated for insulin secretion. At the end of the run-in phase, there were significant reductions in serum total-, LDL-, and HDL-cholesterol (all, p
Faculty
Faculty of Applied Health & Community Studies
School
School of Applied Health
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Copyright
© Angela Kochan
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Original Publication Citation
Kochan, A. (2013). The effects of a low glycemic index diet on glucose tolerance, insulin sensitivity, and intramyocellular lipids in adults with abdominal obesity (Doctoral thesis, University of Toronto, Toronto, ON). Retrieved from https://tspace.library.utoronto.ca/bitstream/1807/35182/1/Kochan_Angela_M_20133_PhD_thesis.pdf
SOURCE Citation
Kochan, Angela Marie, "Effects of a Eucaloric Low Glycemic Index Diet on Insulin Sensitivity and Intramyocellular Lipid Content in Adults with Abdominal Obesity" (2013). Faculty Publications and Scholarship. 2.
https://source.sheridancollege.ca/fahcs_heal_publ/2
