Document Type
Article
Publication Date
2013
Keywords
Cytotoxicity, DNA cleavage, Sparfloxacin, DNA binding, IC50
Abstract
The novel neutral mononuclear copper(II) complexes with fluoroquinolone antibacterial drug, sparfloxacin and nitrogen donor heterocyclic ligand have been synthesized and characterized. An antimicrobial efficiency of the complexes has been tested against five different microorganisms and showed diverse biological activity. The interaction of complex with Herring sperm (HS) DNA was investigated using viscosity titration and absorption titration techniques. The results indicate that the complexes bind to DNA by intercalative mode and have rather high DNA-binding constants. DNA cleavage study showed better cleaving ability of the complexes compare to metal salt and standard drug. All the complexes showed good cytotoxic activity with LC50 values ranging from 4.89 to 11.94 μg mL−1. Complexes also exhibit SOD-like activity with their IC50 values ranging from 0.717 to 1.848 μM.
Faculty
Pilon School of Business
Journal
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Volume
104
First Page
48
Last Page
55
Version
Publisher's version
Peer Reviewed/Refereed Publication
yes
Terms of Use
Terms of Use for Works posted in SOURCE.
Copyright
© Elsevier B.V.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Original Publication Citation
Patel, M. N., Joshi, H. N., Patel, C. R. (2013). Cytotoxic, antibacterial, DNA interaction and superoxide dismutase like activities of sparfloxacin drug based copper(II) complexes with nitrogen donor ligands. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 104, 48 - 55. https://doi-org.library.sheridanc.on.ca/10.1016/j.saa.2012.11.045.
SOURCE Citation
Patel, Mohan N.; Joshi, Hardik N.; and Patel, Chintan R., "Cytotoxic, Antibacterial, DNA Interaction and Superoxide Dismutase Like Activities of Sparfloxacin Drug Based Copper(II) Complexes with Nitrogen Donor Ligands" (2013). Publications and Scholarship. 32.
https://source.sheridancollege.ca/pilon_publ/32