Document Type
Article
Publication Date
2012
Keywords
NS donor ligands, Antimicrobial activity, Nuclease activity, SOD mimic activity, Cytotoxicity, Spectral techniques
Abstract
Square pyramidal Cu(II) complexes with NS donor ligand and ciprofloxacin have been synthesized and characterized using analytical and spectral techniques. The synthesized complexes have been tested for their antimicrobial activity using double dilution technique in terms of minimum inhibitory concentration (MIC) and colony forming unit (CFU). The DNA binding ability of the complexes with Sperm Herring DNA has been performed using absorption titration and viscosity measurement. The nuclease activity of complexes with plasmid DNA (pUC19) has been carried out using agarose gel electrophoresis technique. Synthesized complexes have been tested for their SOD mimic activity using NBT/NADH/PMS system. The cytotoxic properties of metal complexes have been evaluated using brine shrimp lethality bioassay.
Faculty
Pilon School of Business
Journal
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Volume
97
First Page
66
Last Page
73
Version
Publisher's version
Peer Reviewed/Refereed Publication
yes
Terms of Use
Terms of Use for Works posted in SOURCE.
Copyright
© Elsevier B.V.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Original Publication Citation
Patel, M. N., Patel, C. R., Joshi, H. R. (2012). Interaction of drug based copper(II) complexes with Herring Sperm DNA and their biological activities. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 97, 66 - 73. https://doi-org.library.sheridanc.on.ca/10.1016/j.saa.2012.05.037.
SOURCE Citation
Patel, Mohan N.; Patel, Chintan R.; and Joshi, Hardik N., "Interaction of Drug Based Copper(II) Complexes with Herring Sperm DNA and Their Biological Activities" (2012). Publications and Scholarship. 31.
https://source.sheridancollege.ca/pilon_publ/31