Document Type
Article
Publication Date
2012
Keywords
Copper(II) complexes, MICDNA interaction, DNA cleavage activity, Cytotoxicity, Enzymatic behaviour
Abstract
The mixed ligand Cu(II) complexes of ciprofloxacin and N, O donor Schiff bases have been prepared and characterized by physicochemical techniques. In these complexes, ciprofloxacin acts as bidentate deprotonated ligand bound to the metal through the pyridone oxygen and one carboxylate oxygen. The antimicrobial activity of the complexes has been tested on three Gram(− ve) and two Gram(+ ve) microorganisms in terms of minimum inhibitory concentration (MIC) and colony forming unit (CFU). The interaction study of the complexes with Herring Sperm DNA (HS-DNA) has been performed by absorption titration and viscosity measurement. The DNA cleavage activity has been carried out by gel electrophoresis experiment using supercoiled form of pUC19 DNA. Potential cytotoxic effect of complexes has been investigated by brine shrimp lethality assay method. The complexes have been also screened for their enzymatic behaviour in terms of IC50 value.
Faculty
Pilon School of Business
Journal
Inorganic Chemistry Communications
Volume
27
First Page
51
Last Page
55
Version
Publisher's version
Peer Reviewed/Refereed Publication
yes
Terms of Use
Terms of Use for Works posted in SOURCE.
Copyright
© Elsevier B.V.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Original Publication Citation
Patel, M. N., Patel, C. R., Joshi, H. N. (2013). Synthesis, characterization and biological studies of mononuclear copper(II) complexes with ciprofloxacin and N, O donor ligands. Inorganic Chemistry Communications, 27, 51 - 55. https://doi-org.library.sheridanc.on.ca/10.1016/j.inoche.2012.10.018.
SOURCE Citation
Patel, Mohan N.; Patel,, Chintan R.; and Joshi, Hardik N., "Synthesis, Characterization and Biological Studies of Mononuclear Copper(II) Complexes with Ciprofloxacin and N, O Donor Ligands" (2012). Publications and Scholarship. 30.
https://source.sheridancollege.ca/pilon_publ/30