Document Type
Article
Publication Date
2012
Keywords
Terpyridines, Norfloxacin, Antibacterial activity, DNA interaction, SOD mimic
Abstract
The novel octahedral copper(II) complexes with the second generation fluoroquinolone, norfloxacin and terpyridine derivatives were prepared and characterized. The antimicrobial efficiency of the complexes were tested on five different microorganisms and showed good biological activity. Viscosity measurement and absorption titration were employed to determine the mode of binding of complexes with DNA whereas the cleavage efficacy of the complexes towards pUC19 DNA was determined by electrophoresis in presence of ethidium bromide. SOD mimic behaviour was actively sought for clinical and mechanistic purposes under a nonenzymatic system (NBT/NADH/PMS), and was found to have good antioxidant activity.
Faculty
Pilon School of Business
Journal
Journal of Organometallic Chemistry
Volume
701
First Page
8
Last Page
16
Peer Reviewed/Refereed Publication
yes
Terms of Use
Terms of Use for Works posted in SOURCE.
Copyright
© Elsevier B.V
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Original Publication Citation
Patel, M. N., Joshi, H. N., Patel, C. R. (2012). DNA interaction, in vitro antimicrobial and SOD-like activity of copper(II) complexes with norfloxacin and terpyridines. Journal of Organometallic Chemistry 701, 8-16. https://doi-org.library.sheridanc.on.ca/10.1016/j.jorganchem.2011.11.022
SOURCE Citation
Patel, Mohan N.; Joshi, Hardik N.; and Patel, Chintan R., "DNA Interaction, In Vitro Antimicrobial and SOD-like Activity of Copper(II) Complexes with Norfloxacin and Terpyridines" (2012). Publications and Scholarship. 34.
https://source.sheridancollege.ca/pilon_publ/34